Our group is interested in elucidating how the mammalian (epi)genome is maintained throughout cell divisions and how the epigenetic information is translated into spatial chromatin structure and activity during differentiation, reprogramming and disease.
We make use of a variety of biochemical, molecular and cell biological methods with particular emphasis on advanced live-cell and super-resolution fluorescence microscopy.
In the course of our work, we develop new approaches to deliver macromolecules to living cells and establish tools including nanobodies to visualize subcellular structures and cell cycle progression in real time.
New in Nucleic Acids Research!
MBD2 forms liquid condensates that organize heterochromatin and control histone acetylation. Combined proteomics + AI predictions reveal how phase separation regulates chromatin states. MBD2 recruits HDACs, excluding HATs.
doi.org/10.1093/nar/...
