Our group is interested in elucidating how the mammalian (epi)genome is maintained throughout cell divisions and how the epigenetic information is translated into spatial chromatin structure and activity during differentiation, reprogramming and disease.
We make use of a variety of biochemical, molecular and cell biological methods with particular emphasis on advanced live-cell and super-resolution fluorescence microscopy.
In the course of our work, we develop new approaches to deliver macromolecules to living cells and establish tools including nanobodies to visualize subcellular structures and cell cycle progression in real time.
A new way to watch chromatin moving in living stem cells as they become neurons and what we saw was striking. Chromatin literally slows down as cells commit to their fate.
It's like watching cells physically lock in their identity by constraining their chromatin.
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