Our group is interested in elucidating how the mammalian (epi)genome is maintained throughout cell divisions and how the epigenetic information is translated into spatial chromatin structure and activity during differentiation, reprogramming and disease.
We make use of a variety of biochemical, molecular and cell biological methods with particular emphasis on advanced live-cell and super-resolution fluorescence microscopy.
In the course of our work, we develop new approaches to deliver macromolecules to living cells and establish tools including nanobodies to visualize subcellular structures and cell cycle progression in real time.
Post from March 1st: Replication fork protection complex is a key complex for error free DNA replication. Check out our latest work on how Timeless-Tipin complex & interactions with MCM/ RPA mediate DNA replication stresshttps://doi.org/10.3389/fcell.2024.1346534
Post from March 1st : Check out our latest work elucidating the developmental changes in genome replication of Pluripotent versus Differentiated Human Cells Check out the full publication https://doi.org/10.3390/genes15030305
